Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
On the a monthly basis prices fell by an average 0.5 per cent.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
这些各不相同的胡子是设计师弗朗西丝·汉农(Frances Hannon)设计的，在安德森的多部电影中（比如《青春年少》[Rushmore]和《水中生活》[The Life Aquatic With Steve Zissou]），她都为比尔·默里(Bill Murray)设计了面部毛发。这次，她让该片的很多演员留起胡子，供她修剪成任何想要的形状。
"My hair has turned white, half because of housing prices and half because of you reporters." JIANG WEIXIN, member of the CPPCC National Committee and minister of housing and urban-rural development, responding to media questions about government measures to curb housing prices
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
This is the biggest question hanging over the global economy. And the biggest risk.
Belize's proximity to Mexico and the Caribbean ensures the street-food scene, providing an abundance of budget meal options.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
对于新来的买家，这些变化能够给他们带来新的住房选择。但是对于既有居民而言，这可能意味着他们必须搬走。这点同样适用于De Robertis Pasticceria and Caffe等商铺。这家咖啡馆已经在东村(East Village)持续经营了110个年头，最近刚刚关门歇业。到明年，联合广场咖啡厅(Union Square Cafe)也可能会结束其在联合广场30年的运营。
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
'Increased production in the U.S. meant that spot prices weren't reacting quite as much as in previous geopolitical incidents,' Mr. Hansen said. There is so much supply that threats to it have less impact than previously, and 2014 will be 'the first year in a while when supply growth is going to outpace demand growth,' Mr. Hansen said.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
《大城小妞》(Broad City)，Comedy Central，1月14日播出。伊拉纳·格雷泽(Ilana Glazer)与艾比·雅克布逊(Abbi Jacobson)带着第二季回归了，它讽刺了纽约那些大材小用而又自恋的人们生活中的故作姿态、妥协与纯粹粗俗。
“我们的人口和就业正处于历史高位，并在不断增长。这给租金和房价施加了很大压力，”纽约大学富曼房地产及城市政策中心(Furman Center for Real Estate and Urban Policy of New York University)的主任马克·威利斯(Mark Willis)说，“现在没有理由认为这些趋势可能发生改变。”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Attention, travel lovers. You may not have made any travel plans yet, but the choices for next year’s best destinations are already out. Recently, the well-known travel guide publisher Lonely Planet issued its Best in Travel 2014 selection. Here, we pick a few countries from its top 10 list to give you a taste.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
The latest survey also showed the country had a narrower gap between genders in 2015. As to the structure of genders, the male-to-female ratio last year was 105.02, lower than the 2010 ratio of 105.2.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
9. 米拉-库尼斯 1100万美元
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
New York's inactivity begs two questions. Does Jackson have the energy needed to undo the damage he's created during his tenure?
Antiviral drug discovery: broad-spectrum drugs from nature
Restaurants and other retailers across the United States are offering free or discounted items and service to the nation's military veterans Wednesday in honor of the annual Veterans Day holiday observance.
毫无疑问，全世界的肠胃病学家都会感谢Emmanuel Ben-Soussan和Michel Antonietti，因为他们的研究给出了医生该如何进行结肠镜检查的推荐，从而让他们的病人发生气体爆炸的可能性降至最低。
Just because the job market is tough doesn't mean it's impossible. "You have to work harder at the job search," Challenger said.
Influenza neuraminidase: A druggable target for natural products
New Year's greetings and best wishes!
《国土安全》(Homeland)：第三季末布洛迪（Brody，戴米恩·路易斯[Damian Lewis]饰）最终被杀后，映时频道(Showtime)的这部间谍惊悚剧似乎走到了尽头。目前看来，第四季没了他却变得充满活力，令人喜爱。卡莉（Carrie，克莱尔·丹尼斯[Claire Danes]饰）这次的对手是美貌、狡猾的巴基斯坦情报官塔斯尼姆（Tasneem，尼姆拉特·考尔[Nimrat Kaur]饰）。
Total shipments of cellphones reached 560 million in 2016, up 8% year on year, the report showed.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
11. Our gut bacteria are messing with us in ways we could never have imagined. New research has revealed that neurodegenerative diseases like Parkinson's might actually start out in the gut, rather than the brain, and there's mounting evidence that the human microbiome could be to blame for chronic fatigue syndrome. With gut bacteria showing signs of controlling our appetite, changing our brain structure, and triggering brain lesions that could lead to strokes, our tiny passengers are a force to be reckoned with.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
If 2017 was the year policymakers began to worry about the growth of the “precariat”, 2018 will be the year they try to do something about it.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Alternative fuels: For the first time since diesel-powered cars from Europe started arriving here in the 1950s, old first-person accounts about the joys of driving a diesel fall off to near zero. They are replaced by new first-person accounts about the joys of driving cars with ridiculously high horsepower like the 580-hp Chevrolet Camaro ZL1 and Dodge’s Challenger SRT Hellfire with 707 hp. Elsewhere: fuel-cell cars with their longer cruising range move center-stage, stealing the limelight from battery-powered cars.
Congress will authorize billions more in stimulus that won't be called 'stimulus' and won't actually create jobs. And Congress will convene a bi-partisan deficit cutting commission that won't do much either. Until investors stop buying US Treasurys, why should Congress change its ways?
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
In comments reported by state news agency Xinhua on Thursday from a speech given at a meeting of regional leaders in Cambodia on Wednesday, Mr Li said the Chinese economy had performed above expectations in 2017 as trade reversed two years of declines.
The index fell from 50.4 in October to a six-month low of 50.0.
Latest data from the US Treasury Department shows that India held securitie sworth $80 billion in September and further reduced its exposure to $77.5billion in October -- which is also a three-month low.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
While 221 people fell off the billionaires list this year, 198 people joined the ranks. Twenty-nine from the 2015 list died, while another 29 rejoined the list after having fallen off.
Inhibition of SARS coronavirus helicase by bismuth complexes
Goldie Blox is a toy company on a mission to redefine the “pink aisle” in toy stores. Men dramatically outnumber women in science, technology, engineering and math (STEM) education and careers, with girls largely losing interest in these topics by age 8. Goldie Blox toys are designed to inspire future engineers by engaging girls in a way that draws on their strong verbal and storytelling skills — while still offering opportunities to build the skills that can later translate into an interest in engineering. And speaking of opportunity, how does a start-up toy company stand out against the big names that have been dominating the toy space since the beginning of time? In a savvy move, Goldie Blox recently released a video that went viral with their take on the Beastie Boys song “Girls.” Though the video was ultimately taken down, Goldie Blox did an excellent job raising awareness of the need to get more women and girls interested in STEM … and of the Goldie Blox toys.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Dachis says: 2011 saw a huge bounce for Dominos in brand enthusiasm from their brand relaunch which 2012 just couldn’t match. It’s a shame they can’t redesign their recipes every year.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
"Well, I believe I am a feminist because I believe that women deserve the same rights as men in every aspect of our economy and our society, here at home and around the world," Clinton said to applause. "You know, I've devoted a lot of my public life to advocating for women's rights being human rights, and making the case that we have to do everything we can, through laws, regulations, culture, to change the still-existing stereotypes that hold women back."
今年的英国《金融时报》和麦肯锡年度最佳商业图书奖(Financial Times and McKinsey Business Book of the Year Award)，颁给了一部描写前美联储(Fed)主席艾伦.格林斯潘(Alan Greenspan)的传记，其内容引人入胜、面面俱到。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Best chances: Dafoe is probably the current front runner for best supporting actor.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
When the federal government shuttered in October, Starbucks (SBUX, Fortune 500)CEO Howard Schultz refused to sit on the sidelines while businesses everywhere suffered. Instead, Schultz wrote a petition calling on his peers to rally together and put pressure on Congress to come to an agreement.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Will the 10-year Treasury yield finish the year above 3 per cent
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Here are the 10 bogies, drones targeting markets, stocks, bonds and the, global economy:
Besides, Japan and the United States are still innovation hot spots and chemical, semiconductor and electronic components and autos are the top innovative industries, according to the report.
No Bad Manners Awards could be complete without a mention of a Kardashian, could it?
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
So what does 2015 portend? Here are some educated guesses.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
London, meanwhile, is expected to welcome 18.88 million visitors this year.
持有40亿美元亚洲相关资产的美国投资机构Cohen & Steers的基金经理梁纬濂(William Leung)认同这一点。他主张，随着价格下跌，投机性投资将被驱逐出市场。他补充称，行业中另类投资热度上升的趋势应当意味着，即便基础资产的价值上涨得更慢，房地产投资信托的价格也会上升。“我们认为，这次调整的幅度将不会太大，”他说。
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Switzerland, Sweden and the UK again occupied the top three slots in the ranking. Fifteen of the top 25 economies in the GII come from Europe.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The Fate of the Furious was the top-grossing foreign film, ranking second on the list.
“研究数据时，我不断回到这个问题上来，它其实是个身份政治问题，”挪威卑尔根大学(University of Bergen)研究欧洲极右翼党派的教授伊丽莎白?伊法斯夫拉腾(Elisabeth Ivarsflaten)说。“这是民粹主义者获得支持的最有力的征兆。”
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
No matter whether you’re looking for big international events, delicious food, natural wonders or simply relaxation on a beach, these places should be on your checklist.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
More than 27,000 vacancies are offered by over 120 central departments and their affiliated public institutions in the 2017 civil servant recruitment drive. The number of vacancies is about the same as 2016.
“He’s had more of a sense of swagger and confidence” in recent months, says Jan Dawson of Jackdaw Research.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Prior to the slowdown that began in 2014 employers in China had been less stingy with cash bonuses, which can total well over a full month’s salary and send employees back home for the holiday with plenty of cash for gifts to elders and other family members (or to squirrel away as savings).
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
9. The brain literally starts eating itself when it doesn't get enough sleep. Chronic sleep deprivation causes the 'clearing' process that usually happens when we sleep to kick into hyperdrive, prompting the brain to clear a huge amount of neurons and synaptic connections away.
The central government is planning to establish a bond market connect between the mainland and Hong Kong Special Administrative Region on a trial basis this year, allowing for the first time overseas capital to access mainland bond markets from overseas. Hong Kong will be the first to benefit from such an arrangement
Type D personalities usually have a low self-esteem and a great fear of disapproval and this is the primary reason that prevents them from opening up to others.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
It remains the world's largest country and the largest oil producer. It retains its permanent seat on the UN Security Council. Its nuclear arsenal (in Cold War times one of five countries, but now one of nine) has been progressively modernised. Sustained increases in defence spending have brought it close to its goal of escalation dominance in local and regional war.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
New Year should be a time of banked-up fines, the scent of flowers and wine, good talk, good memories and loyalties renewed. But if all else is lacking - love will do.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
There was no immediate word from the Romney camp on the reported results。
伦敦商学院在所有这4项排名上表现强劲，包括全日制MBA课程排名第一，合办EMBA（与美国哥伦比亚商学院(Columbia Business School)合办）和定制高管教育课程均排名第三。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Strengthening the all-around improvement of government
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
EMBAGlobal is the only programme in the top 10 that saw a slight drop in the average salary of its alumni compared with last year (the other nine recorded strong increases).
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
What Mr Ravenscroft liked about it when he was choosing his graduate career path was that it of-fered the best of two worlds. He would be fast-tracked into the classroom, earning a salary, being mentored by an executive from the private sector and making contacts with business; in return, he would commit to teaching for two years and complete a teacher training qualification.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The Jungle Book will be released worldwide on April 15, 2016.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
2. paparazzo /[复] paparazzi / n . 专门追逐名人偷拍照片的摄影者(或记者)，狗仔队。
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
A lone European telephone bidder paid a top price of 9.1 million for a smaller 1825 version of John Constable’s admired but difficult-to-love 1824 vertical landscape, “The Lock,” that had been in the same British family since 1855.
Anti-HIV drug repurposing against SARS-CoV-2
“Right now the fitness tracker isn’t on that list,” he says, “but the next generation of wearables has the potential to pass that critical milestone.”
Attractions: Food, culture and scary stories
It's the summer of 1983, and precocious 17-year-old Elio Perlman is spending the days with his family at their 17th-century villa in Lombardy, Italy. He soon meets Oliver, a handsome doctoral student who's working as an intern for Elio's father. Amid the sun-drenched splendor of their surroundings, Elio and Oliver discover the heady beauty of awakening desire over the course of a summer that will alter their lives forever.
Length-scale dependence of protein hydration-shell density
David said: ‘It was wonderful, you couldn’t fault it. It was perfection.’
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
After years working with large consumer product companies like Stride Rite and Keds, Pieri grew frustrated with the difficulty mom-and-pop shops had launching new products. "The more innovative a product—as opposed to mainstream and "known"—the harder it was to get distribution," she explains. In response, she launched The Grommet, a discovery platform that connects customers with inventors' stories and their products, five years ago. Pieri, whose company helped launch products including SodaStream and Fitbit, counts HP CEO Meg Whitman as a mentor and has a side-gig as an entrepreneur in residence at Harvard Business School.
PRICE PER SQUARE FOOT: $667
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
I wish you a happy New Year. All affection and best wishes to you and yours.
Usually sober-minded analysts, accustomed to the auto industry’s slow growth, seem to shed their inhibitions when it comes to Tesla. Rod Lache of Deutsche Bank has attached a $310 price target on the stock. Not to be out-done, Adam Jonas of Morgan Stanley established a $320 price target and calls Tesla it the “most important car company in the world”.
Summly attempts to solve this problem by creating “snapshots” of stories that allow readers to browse more quickly than reading full articles. The app will close down but Mr D’Aloisio’s technology will be integrated into Yahoo’s mobile apps.
About this collection
People with Type A personalities are often high-achieving "workaholics". They push themselves with deadlines, and hate both delays and ambivalence. People with Type A personalities experience more job-related stress and less job satisfaction.