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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

creative
On the a monthly basis prices fell by an average 0.5 per cent.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

这些各不相同的胡子是设计师弗朗西丝·汉农(Frances Hannon)设计的,在安德森的多部电影中(比如《青春年少》[Rushmore]和《水中生活》[The Life Aquatic With Steve Zissou]),她都为比尔·默里(Bill Murray)设计了面部毛发。这次,她让该片的很多演员留起胡子,供她修剪成任何想要的形状。
"My hair has turned white, half because of housing prices and half because of you reporters." JIANG WEIXIN, member of the CPPCC National Committee and minister of housing and urban-rural development, responding to media questions about government measures to curb housing prices

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 深圳:8月二手楼成交首破7000套
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

The Post

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

事实上,去往俄罗斯有许多可供选择的廉价航班。其国内的西伯利亚大铁路也使得交通十分便利。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

This is the biggest question hanging over the global economy. And the biggest risk.
再来看一下流失顾客的公司吧。
美国整体排名第七,是世界最大经济体,也是世界最强国。“创业精神”排名第三,“文化影响力”也排名第三。
Belize's proximity to Mexico and the Caribbean ensures the street-food scene, providing an abundance of budget meal options.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 建材功能被“放大”也是不守诚信
Perspective

Trends and targets in antiviral phototherapy

inspiring
你是否经常闷闷不乐、心情不好?
[str?uk]
因此,D型人格的人并不是缺乏社交兴趣,而是可能对别人感兴趣,但又害怕接近别人,因为他们害怕被拒绝。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

《哈利·波特》粉们,福利来啦!该片是《哈利·波特》前传,讲述了纽特·斯卡曼德在老纽约的冒险经历。该片根据《哈利·波特》中霍格沃兹学院的同名教科书改编而成。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

对于新来的买家,这些变化能够给他们带来新的住房选择。但是对于既有居民而言,这可能意味着他们必须搬走。这点同样适用于De Robertis Pasticceria and Caffe等商铺。这家咖啡馆已经在东村(East Village)持续经营了110个年头,最近刚刚关门歇业。到明年,联合广场咖啡厅(Union Square Cafe)也可能会结束其在联合广场30年的运营。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

'Increased production in the U.S. meant that spot prices weren't reacting quite as much as in previous geopolitical incidents,' Mr. Hansen said. There is so much supply that threats to it have less impact than previously, and 2014 will be 'the first year in a while when supply growth is going to outpace demand growth,' Mr. Hansen said.
尽管在奥巴马担任美国总统的过去的四年里,美国经济复苏缓慢、失业率居高不下,奥巴马在几个关键的摇摆州获得的选票还是高于罗姆尼。美国选民在两种风格明显迥异的国家发展愿景中做出了自己的决定。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

[sin'si?li]
在北大和清华大学之后,中国内地入选该榜单前20名的院校还有中国科学技术大学,该校位居第15位;复旦大学排名第16位,上海交通大学排名第18位,而浙江大学排名第19。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 6月:入手家居建材时机刚好
Open Access Review Article

Diagnostic technologies for COVID-19: a review

《大城小妞》(Broad City),Comedy Central,1月14日播出。伊拉纳·格雷泽(Ilana Glazer)与艾比·雅克布逊(Abbi Jacobson)带着第二季回归了,它讽刺了纽约那些大材小用而又自恋的人们生活中的故作姿态、妥协与纯粹粗俗。
“我们的人口和就业正处于历史高位,并在不断增长。这给租金和房价施加了很大压力,”纽约大学富曼房地产及城市政策中心(Furman Center for Real Estate and Urban Policy of New York University)的主任马克·威利斯(Mark Willis)说,“现在没有理由认为这些趋势可能发生改变。”

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Attention, travel lovers. You may not have made any travel plans yet, but the choices for next year’s best destinations are already out. Recently, the well-known travel guide publisher Lonely Planet issued its Best in Travel 2014 selection. Here, we pick a few countries from its top 10 list to give you a taste.
在桑迪飓风登陆新泽西Mantoloking之后的早晨,洪水包围了Mantoloking大桥附件的房屋。
charter
凯文·杜兰特

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

The latest survey also showed the country had a narrower gap between genders in 2015. As to the structure of genders, the male-to-female ratio last year was 105.02, lower than the 2010 ratio of 105.2.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

9. 米拉-库尼斯 1100万美元
……又唱又跳,希望能得到工作。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

单词available 联想记忆:

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

New York's inactivity begs two questions. Does Jackson have the energy needed to undo the damage he's created during his tenure?

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Restaurants and other retailers across the United States are offering free or discounted items and service to the nation's military veterans Wednesday in honor of the annual Veterans Day holiday observance.
毫无疑问,全世界的肠胃病学家都会感谢Emmanuel Ben-Soussan和Michel Antonietti,因为他们的研究给出了医生该如何进行结肠镜检查的推荐,从而让他们的病人发生气体爆炸的可能性降至最低。
据新华社报道,全国青少年校园足球办公室近日表示,2016年中国已经拥有13381所“足球专业学校”,而69个区县正在学校里试点足球项目。
Just because the job market is tough doesn't mean it's impossible. "You have to work harder at the job search," Challenger said.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

New Year's greetings and best wishes!
单词addition 联想记忆:
《国土安全》(Homeland):第三季末布洛迪(Brody,戴米恩·路易斯[Damian Lewis]饰)最终被杀后,映时频道(Showtime)的这部间谍惊悚剧似乎走到了尽头。目前看来,第四季没了他却变得充满活力,令人喜爱。卡莉(Carrie,克莱尔·丹尼斯[Claire Danes]饰)这次的对手是美貌、狡猾的巴基斯坦情报官塔斯尼姆(Tasneem,尼姆拉特·考尔[Nimrat Kaur]饰)。
读:游艇
Total shipments of cellphones reached 560 million in 2016, up 8% year on year, the report showed.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 家居电商消费今年或超2000亿元
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

adult成熟的,escent开始…的-开始成熟的-青春期的a,do,lescent=lesson:还在上课的年龄-青春期的
《王冠》

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

11. Our gut bacteria are messing with us in ways we could never have imagined. New research has revealed that neurodegenerative diseases like Parkinson's might actually start out in the gut, rather than the brain, and there's mounting evidence that the human microbiome could be to blame for chronic fatigue syndrome. With gut bacteria showing signs of controlling our appetite, changing our brain structure, and triggering brain lesions that could lead to strokes, our tiny passengers are a force to be reckoned with.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

If 2017 was the year policymakers began to worry about the growth of the “precariat”, 2018 will be the year they try to do something about it.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

单词campaign 联想记忆:
不过,对韩国和东盟(Asean)国家的出口都下滑了约3%,而对香港的转口贸易下滑幅度逾16%。
Alternative fuels: For the first time since diesel-powered cars from Europe started arriving here in the 1950s, old first-person accounts about the joys of driving a diesel fall off to near zero. They are replaced by new first-person accounts about the joys of driving cars with ridiculously high horsepower like the 580-hp Chevrolet Camaro ZL1 and Dodge’s Challenger SRT Hellfire with 707 hp. Elsewhere: fuel-cell cars with their longer cruising range move center-stage, stealing the limelight from battery-powered cars.
Congress will authorize billions more in stimulus that won't be called 'stimulus' and won't actually create jobs. And Congress will convene a bi-partisan deficit cutting commission that won't do much either. Until investors stop buying US Treasurys, why should Congress change its ways?

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

In comments reported by state news agency Xinhua on Thursday from a speech given at a meeting of regional leaders in Cambodia on Wednesday, Mr Li said the Chinese economy had performed above expectations in 2017 as trade reversed two years of declines.
近日,英国《金融时报》披露了中国北方很多地区例行公布的关于国内生产总值(GDP)的虚假数据。在那些地区,可靠的替代证据表明,地方政府“抹平”了经济增长数字。他们人为地推高了2012年至2016年期间的增长数字,掩盖了真实的低迷期,去年又掩盖了真正的复苏。
The index fell from 50.4 in October to a six-month low of 50.0.
Latest data from the US Treasury Department shows that India held securitie sworth $80 billion in September and further reduced its exposure to $77.5billion in October -- which is also a three-month low.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

decline
While 221 people fell off the billionaires list this year, 198 people joined the ranks. Twenty-nine from the 2015 list died, while another 29 rejoined the list after having fallen off.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Goldie Blox is a toy company on a mission to redefine the “pink aisle” in toy stores. Men dramatically outnumber women in science, technology, engineering and math (STEM) education and careers, with girls largely losing interest in these topics by age 8. Goldie Blox toys are designed to inspire future engineers by engaging girls in a way that draws on their strong verbal and storytelling skills — while still offering opportunities to build the skills that can later translate into an interest in engineering. And speaking of opportunity, how does a start-up toy company stand out against the big names that have been dominating the toy space since the beginning of time? In a savvy move, Goldie Blox recently released a video that went viral with their take on the Beastie Boys song “Girls.” Though the video was ultimately taken down, Goldie Blox did an excellent job raising awareness of the need to get more women and girls interested in STEM … and of the Goldie Blox toys.
我们发展出人工记录声音的技术已经有几十年了,但是人工植入器官在耳朵这一领域没有任何改变。你可能认为生长在头两边的肉块极易替换,因为它们只是皮和软骨,而不是复杂的器官。事实上,科学家在制作假耳上并没有做得非常出色。传统的替代耳朵看起来或感觉起来都像塑料玩具。
4、慧眼识香。邦德眼光敏锐,能辨认出孰敌孰友。这种品质常见于性开放者。007很容易识出对他有意的女人,有科学证明,帅哥往往擅长于此。
收集了一些明星们挑选南瓜的相片。看看这些照片,然后告诉我们:你准备好庆祝周三的万圣节了吗
单词comfort 联想记忆:

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

选择出国继续学习的学生比例也出现小幅下降,由去年的4.8%下降至3.4%。
Dachis says: 2011 saw a huge bounce for Dominos in brand enthusiasm from their brand relaunch which 2012 just couldn’t match. It’s a shame they can’t redesign their recipes every year.
在土耳其问题上,普京表示,他看不到与现任土耳其领导人消除紧张关系的可能性。土耳其不久前击落了一架俄罗斯战机。他说,他非常震惊地看到,土耳其非但没有对其行为做出解释,反而转向北约寻求帮助。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

benefit
中国国家旅游局周五发出通知,确认了最近几个月中国游客因所持旅游文件不完整而被拒进入韩国济州岛的报道。该机构提醒中国公民“慎重选择旅游目的地”。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 京西南公路大修 5项工程开工
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

"Well, I believe I am a feminist because I believe that women deserve the same rights as men in every aspect of our economy and our society, here at home and around the world," Clinton said to applause. "You know, I've devoted a lot of my public life to advocating for women's rights being human rights, and making the case that we have to do everything we can, through laws, regulations, culture, to change the still-existing stereotypes that hold women back."
冲击奖项:很难相信斯特里普得不到最佳女主角提名,而汉克斯在销声匿迹几年后,早该获得一项表演类提名了。
今年的英国《金融时报》和麦肯锡年度最佳商业图书奖(Financial Times and McKinsey Business Book of the Year Award),颁给了一部描写前美联储(Fed)主席艾伦.格林斯潘(Alan Greenspan)的传记,其内容引人入胜、面面俱到。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

[ri'vi?in]
Best chances: Dafoe is probably the current front runner for best supporting actor.
单词invigorate 联想记忆:

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

俄罗斯为世界上第十大经济体,除了天然气(碳氢化合物),经济贡献甚微。腐败和寻租行为使经济蒙受巨大损失。它依然沿用着苏联时代的基础设施,并且满足国民教育、医疗需求的能力正急速下滑。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

When the federal government shuttered in October, Starbucks (SBUX, Fortune 500)CEO Howard Schultz refused to sit on the sidelines while businesses everywhere suffered. Instead, Schultz wrote a petition calling on his peers to rally together and put pressure on Congress to come to an agreement.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Will the 10-year Treasury yield finish the year above 3 per cent
2月1日

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

民调显示,荷兰选举将是一场胶着战。吕特所属的中右翼自由民主人民党在大多数民调中位居榜首,但仅领先自由党3个百分点。大多数民调显示很大一部分选民仍未做出决定。
Here are the 10 bogies, drones targeting markets, stocks, bonds and the, global economy:
Besides, Japan and the United States are still innovation hot spots and chemical, semiconductor and electronic components and autos are the top innovative industries, according to the report.
No Bad Manners Awards could be complete without a mention of a Kardashian, could it?

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

So what does 2015 portend? Here are some educated guesses.
用走私野生动物制成的商品到哪里去了?

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

London, meanwhile, is expected to welcome 18.88 million visitors this year.
持有40亿美元亚洲相关资产的美国投资机构Cohen & Steers的基金经理梁纬濂(William Leung)认同这一点。他主张,随着价格下跌,投机性投资将被驱逐出市场。他补充称,行业中另类投资热度上升的趋势应当意味着,即便基础资产的价值上涨得更慢,房地产投资信托的价格也会上升。“我们认为,这次调整的幅度将不会太大,”他说。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Switzerland, Sweden and the UK again occupied the top three slots in the ranking. Fifteen of the top 25 economies in the GII come from Europe.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

这家总部位于伊利诺伊州皮奥利亚的重型机械制造商于1月份批准了100亿美元的股票回购,预计将在今年一季度回购17亿股股票,以完成先前75亿美元的回购计划。公司CEO道格o奥伯赫尔曼表示,正在进行的回购是“我们的现金流创纪录的结果”。(财富中文网)
ex出,ceed走-走出去到美国学习-超过一般人
The Fate of the Furious was the top-grossing foreign film, ranking second on the list.
“研究数据时,我不断回到这个问题上来,它其实是个身份政治问题,”挪威卑尔根大学(University of Bergen)研究欧洲极右翼党派的教授伊丽莎白?伊法斯夫拉腾(Elisabeth Ivarsflaten)说。“这是民粹主义者获得支持的最有力的征兆。”

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

No matter whether you’re looking for big international events, delicious food, natural wonders or simply relaxation on a beach, these places should be on your checklist.
Sebastian Payne

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

一家国际医学杂志撤销了107篇中国学术论文,由此引发了人们对中国学术诚信的关注。被撤稿的作者多数是临床医生。
More than 27,000 vacancies are offered by over 120 central departments and their affiliated public institutions in the 2017 civil servant recruitment drive. The number of vacancies is about the same as 2016.
“He’s had more of a sense of swagger and confidence” in recent months, says Jan Dawson of Jackdaw Research.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

《胡润百富榜》追踪逾2000名净财富在3亿美元或以上的民营企业家,今年的榜单新增了179位富豪。
2014年最佳引擎榜单的其他入选者还包括宝马5系豪华轿车和紧凑型雪佛兰科鲁兹(Cruze)所使用的涡轮增压柴油发动机,保时捷Cayman双座运动跑车的水平对置2.7升6缸发动机以及大众汽车捷达紧凑车的1.8升4缸涡轮增压发动机。
商务部本月早些时候表示,消费品的零售销售是去年消费的一项关键指标。该销售额同比增长了10.7%,占去年全国66.4%的GDP增长。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

n. 远景,看法,透视
Prior to the slowdown that began in 2014 employers in China had been less stingy with cash bonuses, which can total well over a full month’s salary and send employees back home for the holiday with plenty of cash for gifts to elders and other family members (or to squirrel away as savings).

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

9. The brain literally starts eating itself when it doesn't get enough sleep. Chronic sleep deprivation causes the 'clearing' process that usually happens when we sleep to kick into hyperdrive, prompting the brain to clear a huge amount of neurons and synaptic connections away.
The central government is planning to establish a bond market connect between the mainland and Hong Kong Special Administrative Region on a trial basis this year, allowing for the first time overseas capital to access mainland bond markets from overseas. Hong Kong will be the first to benefit from such an arrangement
Type D personalities usually have a low self-esteem and a great fear of disapproval and this is the primary reason that prevents them from opening up to others.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

深入推进“互联网+”行动和国家大数据战略;
Iese商学院的优势之一是其学风严谨。这所位于巴塞罗那的商学院在定制课程的所有指标上一贯表现优异。该校在15项指标中的11项上都跻身前五之列,并在国际客户和师资多样性两项指标上排名第一。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 6月建材家居销售同比下跌17%
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

王斌表示,去年母婴传播率也达到了历史最低点,从2012年的7.1%下降到2017年的4.9%。
It remains the world's largest country and the largest oil producer. It retains its permanent seat on the UN Security Council. Its nuclear arsenal (in Cold War times one of five countries, but now one of nine) has been progressively modernised. Sustained increases in defence spending have brought it close to its goal of escalation dominance in local and regional war.
你可能觉得夏威夷航空的运营相对容易,因为该公司的航班很少遇到美国大陆那种恶劣的天气条件。夏威夷航空公司在航班准点率排行榜上常年位居前列,在9月份最新公布的榜单上创下最高准点率。夏威夷航空公司最近宣布将把业务拓展到夏威夷岛外,开通从檀香山到北京的直达航班。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

谁被埋葬在这里?

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 木塑复合材料:绿色建筑的领头羊
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

她说,“在未来12到24个月,除非这些瓶颈得到解决,否则西得克萨斯中质油价格会跌至每桶50美元,这将促使产油国减产。”
New Year should be a time of banked-up fines, the scent of flowers and wine, good talk, good memories and loyalties renewed. But if all else is lacking - love will do.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

There was no immediate word from the Romney camp on the reported results。
伦敦商学院在所有这4项排名上表现强劲,包括全日制MBA课程排名第一,合办EMBA(与美国哥伦比亚商学院(Columbia Business School)合办)和定制高管教育课程均排名第三。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

你可以在AskMen.com网站上看到完整榜单。以下是最性感女人前十名:
After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

相比之下,新兴市场出口的平均单价差不多自2012年中以来就一直呈同比下降趋势,2016年2月同比降幅达到16.4%。
Strengthening the all-around improvement of government

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

4=是

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

据BT下载网站TorrentFreak数据显示,《权力的游戏》每集平均下载人数有590万。这个数字还不包括在线视频和cyberlocker的下载方式,如果算上这种方式,数据将会更高。而《权力的游戏》每一集的平均收视人数才550万。
昨日发布的新数据是对2015年全球贸易图景的第一张快照。但在这些数据发布之际,有越来越多的人担心2016年对全球经济而言将比此前预期的更为危机四伏。
EMBAGlobal is the only programme in the top 10 that saw a slight drop in the average salary of its alumni compared with last year (the other nine recorded strong increases).
国务院总理李克强在上周五由人力资源和社会保障部组织的一次会议上表示,要优先促进就业。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

What Mr Ravenscroft liked about it when he was choosing his graduate career path was that it of-fered the best of two worlds. He would be fast-tracked into the classroom, earning a salary, being mentored by an executive from the private sector and making contacts with business; in return, he would commit to teaching for two years and complete a teacher training qualification.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

对气候变化持怀疑态度的人长期以来认为,全球气温已在1998年左右停止变暖,那年是20世纪最热的一年,原因是异常强大的厄尔尼诺现象。华盛顿的一些政客用这种说法作为不对温室气体排放采取行动的理由。
寨卡病毒的后果
门票很快销售一空,只是大多却不是落到铁杆球迷的手中。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

另一个出人意料的新领域是纳米技术。
The Jungle Book will be released worldwide on April 15, 2016.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

汇丰发布的正式PMI指数从10月份的50.4降至11月份的50.0,这是6个月内的最低读数。
2. paparazzo /[复] paparazzi / n . 专门追逐名人偷拍照片的摄影者(或记者),狗仔队。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

A lone European telephone bidder paid a top price of 9.1 million for a smaller 1825 version of John Constable’s admired but difficult-to-love 1824 vertical landscape, “The Lock,” that had been in the same British family since 1855.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

“Right now the fitness tracker isn’t on that list,” he says, “but the next generation of wearables has the potential to pass that critical milestone.”
Attractions: Food, culture and scary stories
It's the summer of 1983, and precocious 17-year-old Elio Perlman is spending the days with his family at their 17th-century villa in Lombardy, Italy. He soon meets Oliver, a handsome doctoral student who's working as an intern for Elio's father. Amid the sun-drenched splendor of their surroundings, Elio and Oliver discover the heady beauty of awakening desire over the course of a summer that will alter their lives forever.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

David said: ‘It was wonderful, you couldn’t fault it. It was perfection.’
2016年中国迅猛发展的网红经济可能会达到87亿美元
摩根大通公司下滑至第4名,其总综合得分位居中国农业银行之后。去年名列前10强的两家欧企——荷兰皇家壳牌和汇丰控股,今年仅分别排名11名和14名。
这句话最流行的变体是“别迷恋姐,姐只是个传说。”

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 外交部举行雄安新区全球推介活动
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

After years working with large consumer product companies like Stride Rite and Keds, Pieri grew frustrated with the difficulty mom-and-pop shops had launching new products. "The more innovative a product—as opposed to mainstream and "known"—the harder it was to get distribution," she explains. In response, she launched The Grommet, a discovery platform that connects customers with inventors' stories and their products, five years ago. Pieri, whose company helped launch products including SodaStream and Fitbit, counts HP CEO Meg Whitman as a mentor and has a side-gig as an entrepreneur in residence at Harvard Business School.
PRICE PER SQUARE FOOT: $667

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

I wish you a happy New Year. All affection and best wishes to you and yours.
Usually sober-minded analysts, accustomed to the auto industry’s slow growth, seem to shed their inhibitions when it comes to Tesla. Rod Lache of Deutsche Bank has attached a $310 price target on the stock. Not to be out-done, Adam Jonas of Morgan Stanley established a $320 price target and calls Tesla it the “most important car company in the world”.
Summly attempts to solve this problem by creating “snapshots” of stories that allow readers to browse more quickly than reading full articles. The app will close down but Mr D’Aloisio’s technology will be integrated into Yahoo’s mobile apps.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

People with Type A personalities are often high-achieving "workaholics". They push themselves with deadlines, and hate both delays and ambivalence. People with Type A personalities experience more job-related stress and less job satisfaction.
2017年,衡量工业品出厂价格、反映经济活力的主要指标--生产者物价指数(PPI)上涨6.3%,结束了自2012年以来的连续下降态势。2016年PPI下降1.4%。

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